原著論文

2024年

  • M. Minoshima, S.I. Reja, R. Hashimoto, K. Iijima & *K. Kikuchi, “Hybrid Small-Molecule/Protein Fluorescent Probes”, Chem. Rev., 10, 6198-6270 (2024). DOI: 10.1021/acs.chemrev.3c00549 A01
  • M. Furuta, S. Arii, H. Umeda, R. Matsukawa, K. Shizu, H. Kaji, S. A. Kawashima, Y. Hori, T. Tomita, Y. Sohma, H. Mitsunuma & *M. Kanai, “Leuco Ethyl Violet as Self‐Activating Prodrug Photocatalyst for In Vivo Amyloid‐Selective Oxygenation”, Adv. Sci., 2401346 (2024). DOI: 10.1002/advs.202401346 A01
  • F. Pünner, *Y. Sohtome, Y. Lyu, D. Hashizume, M. Akakabe, M. Yoshimura, Y. Yashiroda, M. Yoshida & *M. Sodeoka, “Catalytic Aerobic Carbooxygenation for the Construction of Vicinal Tetrasubstituted Centers: Application to the Synthesis of Hexasubstituted γ-Lactones”, Angew. Chem. Int. Ed., 63, e202405876 (2024). DOI: 10.1002/anie.202405876 A01
  • T. Davie, X. Serrat, L. Imhof, J. Snider, I. Štagljar, J. Keiser, H. Hirano, N. Watanabe, H. Osada & *A.G. Fraser, “Identification of a novel family of species-selective complex i inhibitors as potential anthelmintics”, Nature Commun., 15, 3367 (2024). DOI: 10.1038/s41467-024-47331-3 B01
  • H. Saito, Y. Handa, M. Chen, T. Schneider-Poetsch, Y. Shichino, M. Takahashi, D. Romo, M. Yoshida, A. Fürstner, T. Ito, K. Fukuzawa & S. Iwasaki, “DMDA-PatA mediates RNA sequence- selective translation repression by anchoring eIF4A and DDX3 to GNG motifs”, Nature Commun., 15, 7418 (2024). DOI: 10.1038/s41467-024-51635-9 A01
  • *A.A. Vinogradov, Y. Zhang, K. Hamada, S. Kobayashi, K. Ogata, T. Sengoku, *Y. Goto & *H. Suga, “A compact reprogrammed genetic code for de novo discovery of proteolytically stable thiopeptides”, J. Am. Chem. Soc., 146, 8058-70 (2024). DOI: 10.1021/jacs.3c12037 C01
  • T. Matsushita, S. Kishimoto, K. Hara, H. Hashimoto, H. Yamaguchi, Y. Saito & *K. Watanabe, “Functional enhancement of flavin-containing monooxygenase through machine learning methodology”, ACS. Catal., 14, 6945-6951 (2024). DOI: 10.1021/acscatal.4c00826 B01
  • S.I. Reja, M. Minoshima, Y. Hori & *K. Kikuchi, “Recent Advancements of Fluorescent Biosensors Using Semisynthetic Probes”, Biosens. Bioelectron., 247, 115862 (2024). DOI: 10.1016/j.bios.2023.115862 A01
  • T. Sawazaki, D. Sasaki & *Y. Sohma, “Catalysis Driven by an Amyloid-Substrate Complex”, Proc. Natl. Acad. Sci. U.S.A., 121, e2314704121 (2024). DOI: 10.1073/pnas.2314704121 A01
  • Y. Muraoka & *M. Ueda, “Quick Guide Nyctinasty”, Curr. Biol., 34, R301-R312 (2024). DOI: 10.1016/j.cub.2024.02.047 A01
  • Y. Miura, S. Namioka, A. Iwai, N. Yoshida, H. Konno, Y. Sohma, M. Kanai & *K. Makabe, “Redesign of a Thioflavin-T-binding Protein with a Flat β-Sheet to Evaluate a Thioflavin T-derived Photocatalyst with Enhanced Affinity”, Int. J. Biol. Macromol., 269, 131992 (2024). DOI: 10.1016/j.ijbiomac.2024.131992 A01
  • K. Torii, S. Benson, *Y. Hori, *M. Vendrell & *K. Kikuchi, “No-wash Fluorogenic Labeling of Proteins for Reversible Photoswitching in Live Cells”, Chem. Sci., 15, 1393-1401 (2024). DOI: 10.1039/D3SC04953A A01
  • *K. Watanabe, Q. Mao, Z. Zhang, M. Hata, M. Kodera, H. Kitagishi, T. Niwa & *T. Hosoya, “Clickable bisreactive small gold nanoclusters for preparing multifunctionalized nanomaterials: application to photouncaging of an anticancer molecule”, Chem. Sci., 15, 1402 (2024). DOI: 10.1039/D3SC04365G C01
  • Y. Ohnuki, M. Akiyama & *Y. Sakakibara, “Deep learning of multimodal networks with topological regularization for drug repositioning”, J Cheminform., 16, 103 (2024). DOI: 10.1186/s13321-024-00897-y B01
  • *K.L. Granberg, S. Sakamaki, N. Larsson, F. Bergström, R. Fuchigami, Y. Niwa, E. Ryberg, A. Backmark, H. Kato, S. Miyazaki, K. Iguchi, T. Sakamoto, M. Persson, A. Idei, L.P. Garcia, I.C. Villar, H. Gradén, G. Bergonzini, T. Arvidsson, T. Fujita, M. Althage, J. Ulander, J. Kimura, H. Yoneda, O. Fjellström, H. Mochida & M. La, “Discovery of Clinical Candidate AZD5462, a Selective Oral Allosteric RXFP1 Agonist for Treatment of Heart Failure”, J. Med. Chem., 67, 4419−444 (2024). DOI: 10.1021/acs.jmedchem.3c02184 A01
  • T. Miki, S. Yamamoto, C. Liu, K. Torikai, M. Kinoshita, N. Matsumori & *T. Kawai, “Highly sensitive two-dimensional profiling of N-linked glycans by hydrophilic interaction liquid chromatography and dual stacking capillary gel electrophoresis”, Anal. Chim. Acta, 1320, 342990 (2024). DOI: 10.1016/j.aca.2024.342990 A01
  • Y. Wu, M. Minoshima & *K. Kikuchi, “Development of elliptic core-shell nanoparticles with fluorinated surfactants for 19F MRI”, Front. Chem., 12, 1408509 (2024). DOI: 10.3389/fchem.2024.1408509 A01
  • *S. Matoba, D. Shikata, F. Shirai, T. Tatebe, M. Hirose, A. Nakata, N. Watanabe, A. Hasegawa, A. Ito, M. Yoshida & *A. Ogura, “Reduction of H3K9 methylation by G9a inhibitors improves the development of mouse SCNTembryos”, Stem Cell Reports, 19, 1-16 (2024). DOI: 10.1016/j.stemcr.2024.04.003 A01
  • C. Diehl, C.F. Pinzan, P.A. de Castro, E. Delbaje, L.C. García Carnero, E. Sánchez-León, K. Bhalla, J.W. Kronstad, D-g. Kim, T.L. Doering, S. Alkhazraji, N.N. Mishra, A.S. Ibrahim, M. Yoshimura, L.A. Vega Isuhuaylas, L.T.K. Pham, Y. Yashiroda, C. Boone, T.F. Dos Reis & *G.H. Goldman, “Brilacidin, a novel antifungal agent against Cryptococcus neoformans”, mBio, 15, e0103124 (2024). DOI: 10.1128/mbio.01031-24 A01
  • M. Uehara, T. Inoue, S. Hase, E. Sasaki, A. Toyoda & *Y. Sakakibara, “Decoding host-microbiome interactions through co-expression network analysis within the non-human primate intestine”, mSystem, e0140523 (2024). DOI: 10.1128/msystems.01405-23 B01
  • S. Yeom & *K. Ohmori, “One-Pot Synthesis of Fuctionanalized Benzotropones via Phthalide Ring-Opening/Intramolecular Aldol Condensation Cascade”, Org. Lett., 26, 5120-5124 (2024). DOI: 10.1021/acs.orglett.4c01530 B01
  • T. Kaji, K. Matsumoto, T. Okumura, M. Nakayama, S. Hoshino, Y. Takaoka, J. Wang & *M. Ueda, “Two distinct modes of action of molecular glues in the plant hormone co-receptor COI1-JAZ system”, iScience, 27, 108625 (2024). DOI: 10.1016/j.isci.2023.108625 A01
  • T. Kaji, Y. Nishizato, H. Yoshimatsu, A. Yoda, W. Liang, A. Chini, K. Nozawa, J. Kyozuka, R Solano & *M. Ueda, “Δ4-dn-iso-OPDA, a bioactive plant hormone of Marchantia polymorpha”, iScience, 27, 110191 (2024). DOI: 10.1016/j.isci.2024.110191 A01
  • Q.V. Vu, K. Baba, S. Sasaki, K. Kawaguchi, H. Hirano, H. Osada & *T. Kataoka, “Alantolactone derivatives inhibit the tumor necrosis factor α-induced nuclear factor κb pathway by a different mechanism from alantolactone”, Eur. J. Pharmacol., 969, 176458 (2024). DOI: 10.1016/j.ejphar.2024.176458 B01
  • Q.V. Vu, K. Baba, S. Sasaki, K. Kawaguchi, H. Hirano, H. Osada & *T. Kataoka, “Porphyrin derivatives inhibit tumor necrosis factor α-induced gene expression and reduce　the expression and increase the cross-linked forms of cellular components of the nuclear factor κB signaling pathway”, Eur. J. Pharmacol., 977, 176747 (2024). DOI: /10.1016/j.ejphar.2024.176747 B01
  • G. Yoshimura, J. Sakamoto, M. Kitajima & *H. Ishikawa, “Indole C5-selective Bromination of Indolo[2,3-a] quinolizidine Alkaloids via In Situ-Generated Indoline Intermediate”, Chem. Eur. J., 30, e202401153 (2024). DOI: 10.1002/chem.202401153 C01
  • A. Tučs, T. Ito, Y. Kurumida, S. Kawada, H. Nakazawa, Y. Saito, *M. Umetsu & *K. Tsuda, “Extensive antibody search with whole spectrum black-box optimization”, Sci. Rep., 14, 552 (2024). DOI: 10.1038/s41598-023-51095-z B01
  • N. Kozakai, S. Endo, A. Nakayama & *T. Shinada, “First Total Syntheses of Beauvericin A and allo-Beauvericin A”, ACS Omega, 9, 12228-12236 (2024). DOI: 10.1021/acsomega.4c00278 C01
  • Y. Asano, S. Saito, Y. Ujie, C. Iwata, T. Yaguchi & *M.A. Arai, “Activation of secondary metabolism and protease activity mechanisms in the black koji mold Aspergillus luchuensis through co-culture with animal cells”, ACS Omega, 9, 29−43137 (2024). DOI: 10.1021/acsomega.4c07124 A01
  • M. Morito, H. Yasuda, T. Matsufuji, M. Kinoshita & *N. Matsumori, “Identification of Lipid-Specific Proteins with High-Density Lipid-Immobilized Beads”, Analyst, 149, 3747–3755 (2024). DOI: 10.1039/D4AN00579A A01
  • Y. Sato, X. Shi, Y. Ye, S. Domon, J. Takino, T. Ozaki, *C. Liu, *H. Oikawa & *A. Minami, “Bioinformatics-guided reconstitution of biosynthetic machineries of fungal eremophilane sesquiterpenes”, ACS Chem. Biol., 19, 861-865 (2024). DOI: 10.1021/acschembio.4c00040 C01
  • K. Sakai, Y. Futamura, T. Nogawa, Y. Zhao, H. Koshino, H. Osada & *S. Takahashi, “Production of kinanthraquinone D with antimalarial activity by heterologous gene expression and biotransformation in Streptomyces lividans TK23”, J. Nat. Prod., 87, 855–860 (2024). DOI: 10.1021/acs.jnatprod.3c01076 B01
  • S. Kimura, Y. Watanabe, Y. Kikuchi, S. Shibasaki, H. Tsutsumi, Y. Inahashi, R. Hokari, A. Ishiyama & *M. Iwatsuki, “Akedanones A-C, in vitro and in vivo antiplasmodial 2,3-dihydronaphthoquinones produced by Streptomyces sp. K20-0187”, J. Nat. Prod., 87, 994–1002 (2024). DOI: 10.1021/acs.jnatprod.3c01285 A01
  • E. Fukuda, I. Fujiwara, S. Maruno, K. Motomura, S. Endo, A. Iwasaki, T. Fukuta, *A. Nakayama & *T. Shinada, “Total Synthesis of Bipenicilisorin and Assignment of the Absolute Configuration”, J. Nat. Prod., 87, 1394-1400 (2024). DOI: 10.1021/acs.jnatprod.4c00114 C01
  • A.I. Abdelhakim, Y. Futamura, Y. Asami, H. Hanaki, N. Kito, S. Masuda, A. Shibata, A. Muranaka, H. Koshino, K. Shirasu, H. Osada, J. Ishikawa & *S. Takahashi, “Expression of syo_1.56 sarp regulator unveils potent elasnin derivatives with antibacterial activity”, J. Nat. Prod., 87, 1459-1470 (2024). DOI: 10.1021/acs.jnatprod.4c00259 B01
  • S. Iseki, #H. Ikeda, #S. Kobayashi, K. Irie, H. Harada & *H.Kakeya, “Teleocidin B-4, a PKC activator, upregulates hypoxia-inducible factor 1 (HIF-1) activity by promoting the accumulation of HIF-1α protein via the PKCα/mTOR signaling pathway”, J. Nat. Prod., 87, 1666–1671 (2024).DOI: 10.1021/acs.jnatprod.4c00395 (#equal contribution) A01
  • S. Konno, *F. Ishikawa, H. Kakeya & *G. Tanabe, “Probing for optimal photoaffinity linkers of benzophenone-based photoaffinity probes for adenylating enzymes”, Bioorg. Med. Chem., 110, 117815 (2024). DOI: 10.1016/j.bmc.2024.117815 A01
  • N. Moritsuka, N. Kiya, T. Moriyama, H. Koshino, *M. Yoritate, H. Matoba & *G. Hirai, “Linkage-Editing of Melibiosamine: Synthesis and Biological Evaluation of CH2- and CHF-Linked Analogs”, J. Org. Chem., 89, 11909–11920 (2024). DOI: 10.1021/acs.joc.4c01143 C01
  • R. Saito, M. Morikawa, T. Muto, S. Saito, T. Kaji & *M. Ueda, “SlCYP94B18 and SlCYP94B19 monooxygenases for the catabolic turnover of jasmonates in tomato leaves”, Phytochemistry, 223, 114141 (2024). DOI: 10.1016/j.phytochem.2024.114141 A01
  • S. Miwa, *H. Takikawa, R. Takeuchi, R. Mizunuma, K. Matsuoka, H. Ogawa, *H. Kato & *K. Takasu, “Structure–ATPase activity relationship of rhodamine derivatives as potent inhibitors of P-glycoprotein CmABCB1”, ACS Med. Chem. Lett., 15, 287-293 (2024). DOI: 10.1021/acsmedchemlett.3c00526 C01
  • M. Ozaki, T, Nakade, M. Shimotsuma, A. Ikeda, T. Kuranaga, *H. Kakeya & *T. Hirose, “Simultaneous analysis of DL-amino acids in foods and beverages using a highly sensitive chiral resolution labeling reagent”, J. Chromatogr. B, 1244, 124239 (2024). DOI: 10.1016/j.jchromb.2024.124239 A01
  • *T. Fujiwara, E. Mano & E. Nango, “Structural basis for the minimal bifunctional alginate epimerase AlgE3 from Azotobacter chroococcum” FEBS. Lett., 11, 1422-1437 (2024). DOI: 10.1002/1873-3468.14886 A01
  • *C. Tsukano, A. Uchino & *K. Irie, “Synthesis and application of symmetric amino acid derivatives”, Org. Biomol. Chem., 22, 411-428 (2024). DOI: 10.1039/D3OB01379K C01
  • A. Yamaguchi, N. Obiya, N. Arichi, S. Oishi, H. Ohno & *S. Inuki, “Synthesis of Labionin and Avionin Precursors via Nitrogen-Centred-Radical-Triggered 1,5-HAT Reaction of Tris Derivatives”, Org. Biomol. Chem., 22, 2049-2055 (2024). DOI: 10.1039/d3ob02037a A01
  • K. Kurokawa, N. Ogawa, Y. Kuroda, Y. Yamaoka, H. Takikawa, K. Tsubaki & *K. Takasu, “Chromic Properties of Dibenzo[j,l]fluoranthenes Exhibiting Different Resonance Contributions”, Org. Biomol. Chem., 22, 5306-5313 (2024). DOI: 10.1039/D4OB00750F C01
  • M. Nakahara, S. Watanabe, M. Sato, H. Okumura, M. Kawatani, *H. Osada, K. Hara, *H. Hashimoto & *K. Watanabe, “Structural and functional analyses of inhibition of human dihydroorotate dehydrogenase by antiviral furocoumavirin”, Biochemistry, 63, 1241-1245 (2024). DOI: 10.1021/acs.biochem.4c00120 B01
  • Y. Yoshida, H. Takeuchi, N. Arichi, S. Oishi, H. Ohno & *S. Inuki, “Approach to Spirocyclohexadienes via Visible Light-Mediated ipso-Cyclization of Amino Acid Derivatives with N-(2-Phenyl)benzoyl Groups”, Asian J. Org. Chem., 13, e202400140 (2024). DOI: 10.1002/ajoc.202400140 A01
  • R. Hashimoto, M. Minoshima & *K. Kikuchi, “Rational Design of Hydroxylated Thiazole Orange Photocages for Green Light-Triggered DNA Recombination”, ChemBioChem., 25, e202300799 (2024). DOI: 10.1002/cbic.202300799 A01
  • S. Wangamnuayporn, M. Kinoshita, T. Kawai & *N. Matsumori, “Gold nanoparticle-powered screening of membrane protein-specific lipids from complex lipid mixtures”, Anal. Biochem., 687, 115447 (2024). DOI: 10.1016/j.ab.2023.115447 A01
  • *N. Matsumori, M. Hieda, M. Morito, Y. Wakamiya & T. Oishi, “Truncated derivatives of amphidinol 3 reveal the functional role of polyol chain in sterol-recognition and pore formation”, Bioorg. Med. Chem. Lett., 98, 129594 (2024). DOI: 10.1016/j.bmcl.2023.129594 A01
  • S. Inuki, J. Miyamoto, N. Hashimoto, H. Shimizu, H. Tabuchi, A. Kawai, L. C. Greiner, *I. Kimura & *H. Ohno, “Structure-Activity Relationship Studies of Tetrahydroquinolone Derivatives as GPR41 Modulators”, Bioorg. Med. Chem. Lett., 107, 129758 (2024). DOI: 10.1016/j.bmcl.2024.129758 A01
  • H. Matoba, K. Oba, H. Li, Y. Mizuno, Q. Wang, M. Yoritate, M. Aso, M. Sodeoka, M. Yoshida, *Y. Yashiroda & *G. Hirai, “Structure-activity relationship study of nitrogen signaling factors” Bioorg. Med. Chem. Lett., 109, 129857 (2024). DOI: 10.1016/j.bmcl.2024.129857 A01 C01
  • *Y. Nishigaya, S. Takase, T. Sumiya, T. Sato, H Niwa, S. Sato, A. Nakata, S. Matsuoka, Y. Maemoto, N. Hashimoto, R. Namie, T. Honma, T. Umehara, M. Shirouzu, H. Koyama, M. Yoshida, A. Ito & *F. Shirai, “Structure-based development of novel substrate-type G9a inhibitors as epigenetic modulators for sickle cell disease treatment”, Bioorg. Med. Chem. Lett., 110, 129856 (2024). DOI: 10.1016/j.bmcl.2024.129856 A01
  • Y. Yokota, K. Takaki, K. Baba, S. Sasaki, H. Hirano, H. Osada & *T. Kataoka, “Amiodarone inhibits the toll-like receptor 3-mediated nuclear factor κb signaling pathway by blocking organelle acidification”, Biochem. Biophys. Res. Commun., 708, 149801 (2024). DOI: 10.1016/j.bbrc.2024.149801 B01
  • A. Kishimoto, M. Komiyama, H. Wada, N. Satoh-Asahara, H. Yamakage, H.Aoyama, Y. Katsuura, A. Imaizumi, T. Hashimoto, Y. Sunagawa, T. Morimoto, M. Kanai,
    H. Kakeya     & *K. Hasegawa, “Efficacy of highly bioavailable oral curcumin in asymptomatic or mild COVID-19 patients: A double-blind, randamized, placebo-controlled trial”, J. Health Popul. Nutr., 43, 93 (2024). DOI: 10.1186/s41043-024-00584-6 A01
  • Y. Zhang, *Y. Goto & *H. Suga, “Modulating the acceptor preference of His-C-geranyltransferase LimF”, Isr. J. Chem., e202300182 (2024). DOI: doi/10.1002/ijch.202300182 C01
  • *F. Ishikawa, S. Konno, H. Kakeya & *G. Tababe, “Development of a chemical scaffold for inhibiting nonribosomal peptide synthetases in live bacterial cells”, Beilstein J. Org. Chem., 20, 445-451 (2024). DOI: 10.3762/bjoc.20.39 A01
  • *S. Saito & *M.A. Arai, “Methodology for awakening the potential secondary metabolic capacity in actinomycetes”, Beilstein J. Org. Chem., 20, 753-766 (2024). (Review). DOI: 10.3762/bjoc.20.69 A01
  • S. Suzuki, S. Saito, Y. Narushima, S. Kodani, N. Kagaya, H. Suenaga, K. Shin-ya & *M.A. Arai, “Notch activator cyclopiazonic acid induces apoptosis in HL-60 cells through calcineurin activation”, J. Antibiot., 77, 30-38 (2024). DOI: 10.1038/s41429-023-00673-4 A01
  • #C. Pan, #H. Ikeda, M. Minote, T. Tokuda, T. Kuranaga, T. Taniguchi, N. Shinzato, H. Onaka & *H. Kakeya, “A. Amoxetamide, A new anoikis inducer, produced by combined-culture of Amycolatopsis sp. and Tsukamurella pulmonis”, J. Antibiot., 77, 66-70 (2024). (#equal contribution) DOI: 10.1038/s41429-023-00668-1 A01
  • H. Azami, Y. Watanabe, K. Sakai, H. Nakahara, H. Kojima, T. Tokiwa, K. Nonaka, Y. Noguchi, Y. Nagano, T. Hirose, T. Sunazuka, H. Matsui, N. Arima, K. Abe, H. Hanaki & *M. Iwatsuki, “Antifungal profile against Candida auris clinical isolates of tyroscherin and its new analog produced by the deep-sea-derived fungal strain Scedosporium apiospermum FKJ-0499”, J. Antibiot., 77, 156-162 (2024). DOI: 10.1038/s41429-023-00696-x A01
  • D. Mao, P. Yu, N. Shinzato, L. Zhang, W. Zheng, S. Lu & *H. Kakeya, “Precezomysin, a novel antibiotic biosynthetic precursor of cezomycin, from actinomycete Kitasatospora putterlickiae 10-13”, J. Antibiot., 77, 189-192 (2024). DOI: 10.1038/s41429-023-00695-y A01
  • S.I. Kimura, Y. Watanabe, Y. Mikasa, R. Miyano, T. Tokiwa, K. Nonaka, T. Nakashima, Y. Noguchi, T. Hirose, T. Sunazuka, R. Hokari, A. Ishiyama & *M. Iwatsuki, “Virgaricins C and D, new pramanicin analogs produced by Apiospora sp. FKI-8058”, J. Antibiot., 77, 206-213 (2024). DOI: 10.1038/s41429-023-00699-8 A01
  • S. Kimura, Y. Watanabe, S. Shibasaki, N. Shinzato, Y. Inahashi, T. Sunazuka, R. Hokari, A. Ishiyama & *M. Iwatsuki, “New antimalarial iromycin analogs produced by Streptomyces sp. RBL-0292”, J. Antibiot., 77, 272-277 (2024). DOI: 10.1038/s41429-024-00707-5 A01
  • K. Kaneko, M. Mieda, Y. Jiang, N. Takahashi & *H. Kakeya, “Tumescenamide C, a cyclic lipodepsipeptide from Streptomyces sp. KUSC_F05, exerts antimicrobial activity against the scab-forming actinomycete Streptomyces scabiei” J. Antibiot., 77, 353-364 (2024) (2024). DOI: 10.1038/s41429-024-00716-4 A01
  • S. Lu, L. Ren, D. Mao & * H.Kakeya, “Mechanistic study of the retro-aza-Michael reaction in saccharothriolide L: Identification of 2-amino-4-methylphenol as an effective protecting tool for the Michael acceptor”, J. Antibiot., 77, 544–547 (2024). DOI: 10.1038/s41429-024-00741-3 A01
  • R. Tanaya, T. Kodama, J. Maneenet, Y. Yasuno, A. Nakayama, T. Shinada, H. Takahashi, T. Ito, H. Morita, S. Awale & *F. Taura, “Substrate-Dependent Alteration in the C- and O-Prenylation Specificities of Cannabis Prenyltransferase”, Bio. Pharm. Bull., 47, 449-453 (2024). DOI: 10.1248/bpb.b23-00868 C01
  • *Y. Ando, D. Ogawa, F. Wakita, K. Suzuki & *K. Ohmori, “Photochemical Reaction of 1,2-Naphthoquinone toward Enantioselective Synthesis of g-Rubromycin: Viability Dependence on Chromophore”, Synlett, 35, 441-444 (2024). DOI: 10.1055/a-2113-0212 C01
  • J. Sakamoto, D. Hiruma, M. Kitajima & *H. Ishikawa, “Collective Total Synthesis of b-Carboline-type Monoterpenoid Indole Alkaloid Glycosides”, Synlett, 35, 576–581 (2024). DOI: 10.1055/a-2053-1629 C01
  • N. Kudo, S. Chiba, S. Ono, M. Nagatoishi, M. Yoritate, S. Karasawa, *K. Usui & *G. Hirai, “Stereoselective Synthesis of C-Aryl-α-Glycosides by Reductive C(Sp2)-C(Sp3) Cross-Coupling Reaction”, Synlett, In Press, (2024) DOI: 10.1055/a-2352-4760
  • S. Imaoka, Y. Nakashima, M. Kitajima & *H. Ishikawa, “Bioinspired Total Synthesis of (+)-Kopsiyunnanine B”, Chem. Pharm. Bull., 72, 68–74 (2024). DOI: 10.1248/cpb.c23-00654 C01
  • *A. Nakayama, “Studies on Comprehensive Total Synthesis of Natural and Pseudo-Natural Products for Drug Discovery”, Chem. Pharm. Bull., 72, 422-431 (2024). DOI: 10.1248/cpb.c24-00056 C01
  • *S. Saito, T. Banno & *M.A. Arai, “3-Hydroxy-3-(2-oxopropyl)indolin-2-one, a product of a human-derived Enterocloster strain, is an inhibitor of nitric oxide production”, Biosci. Biotechnol. Biochem., 88, 316-321 (2024). DOI: 10.1093/bbb/zbad172 A01
  • *H. Komaki, H. Takagi, S. Takahashi & H. Osada, “Reclassification of a reveromycin-producer and the proposals of Actinacidiphila reveromycinica sp. nov. and Actinacidiphila acidipaludis comb. nov.”, Biosci. Biotechnol. Biochem., 88,689-695 (2024). DOI: 10.1093/bbb/zbae032 B01
  • Y. Nishizato, Y. Muraoka, M. Morikawa, R. Saito, *T. Kaji & *M. Ueda, “Identification of “modified OPDA (mo-OPDA)” as a Michael adduct of cis-OPDA”, Biosci. Biotechnol. Biochem., 88, 885–891 (2024). DOI: 10.1093/bbb/zbae056 A01
  • T. Katayama, Y. Jiang, *T. Ozaki, *H. Oikawa, *A. Minami & *J. Maruyama, “Subcellular compartmentalized localization of transmembrane proteins essential for production of fungal cyclic peptide cyclochlorotine”, Biosci. Biotechnol. Biochem., 88, 1279-1288 (2024). C01
  • Y. Konishi, Y. Otera, M. Minoshima & *K. Kikuchi, “Activatable 19F MRI Probe for Detection of α-amylase Activity”, Chem. Lett., 53, upae003 (2024). DOI: 10.1093/chemle/upae003 A01
  • H. Shen & *Y. Saito, “Protein-compound interaction prediction using microbial chemical communication network”, IPSJ TBIO., 17, 27-32 (2024). DOI: 10.2197/ipsjtbio.17.27 B01
  • *丹羽節 & *細谷孝充, “PETプローブ開発を指向した分子設計と合成戦略”, 有機合成化学協会誌, 82, 433-449 (2024). DOI: 10.5059/yukigoseikyokaishi.82.433 C01
  • J. Sawamura, D. Ieiri, *R. Yazaki, & *T. Ohshima, “α,β-Dehydroamino Acid Synthesis through Proline-Catalyzed Aldol Condensation with a Glycine Schiff Base”, Precis. Chem., 2, 14–20 (2024). DOI: 10.1021/prechem.3c00048 C01

2023

  • M. Minoshima, T. Umeno, K. Kadooka, M. Roux, N. Yamada & *K. Kikuchi, “Development of a Versatile Protein Labeling Tool for Live-Cell Imaging Using Fluorescent β-Lactamase Inhibitors”, Angew. Chem. Int. Ed., 62, e202301704 (2023). DOI: 10.1002/anie.202301704 A01
  • *Z. Zhang, T. Niwa, K. Watanabe & *T. Hosoya, “11C-Cyanation of Aryl Fluorides via Nickel and Lithium Chloride-Mediated C–F Bond Activation”, Angew. Chem. Int. Ed., 62, e202302956 (2023). DOI: 10.1002/anie.202302956 C01
  • Y. Konishi, M. Minoshima, K. Fujihara, T. Uchihashi & *K. Kikuchi, “Elastic Polymer-coated Nanoparticles with Fast Clearance for 19FMR Imaging”, Angew. Chem. Int. Ed., 62, e202308565 (2023). DOI: 10.1002/anie. 202308565 A01
  • S. Takase, T. Hiroyama, F. Shirai, Y. Maemoto, A. Nakata, M. Arata, S. Matsuoka, T. Sonoda, H. Niwa, S. Sato, T. Umehara, M. Shirouzu, Y. Nishigaya, T. Sumiya, N. Hashimoto, R. Namie, M. Usui, T. Ohishi, S. Ohba, M. Kawada, Y. Hayashi, H. Harada, T. Yamaguchi, Y. Shinkai, Y. Nakamura, *M. Yoshida & *A. Ito, “A specific G9a inhibitor unveils BGLT3 lncRNA as a universal mediator of chemically induced fetal globin gene expression”, Nat. Commun., 14, 23 (2023). DOI: 10.1038/s41467-022-35404-0 A01
  • A. Fadini, C.D.M. Hutchison, D. Morozov, J. Chang, K. Maghlaoui, S. Perrett, F. Luo, J.C.X. Kho, M.G. Romei, R.M.L. Morgan, C.M. Orr, V. Cordon-Preciado, T. Fujiwara, N. Nuemket, T. Tosha, R. Tanaka, S. Owada, K. Tono, S. Iwata, S.G. Boxer, G. Groenhof, *E. Nango & *J.J. van Thor, “Serial Femtosecond Crystallography Reveals that Photoactivation in a Fluorescent Protein Proceeds via the Hula Twist Mechanism”, J. Am. Chem. Soc., 145, 15796-15808 (2023). DOI: 10.1021/jacs.3c02313 A01
  • H. Kuroiwa, S. Suzuki, K. Irie & *C. Tsukano, “Total Synthesis and Structure Revision of (+)-Lancilactone C”, J. Am. Chem. Soc., 145, 14587-14591 (2023). DOI: 10.1021/jacs.3c04124 C01
  • K. Takayama, S. Matsuoka, S. Adachi, T. Honma, M. Yoshida, T. Doi, K. Shin-Ya, M. Yoshida, H. Osada & *S. Inoue, “Identification of small-molecule inhibitors against the interaction of RNA-binding protein PSF and its target RNA for cancer treatment”, PNAS Nexus, 2, 1-10 (2023). DOI: 10.1093/pnasnexus/pgad203 A01B01
  • M. Kato, K. Maeda, R. Nakahara, H. Hirose, A. Kondo, S. Aki, M. Sugaya, S. Hibino, M. Nishida, M. Hasegawa, H. Morita, R. Ando, R. Tsuchida, M. Yoshida, T. Kodama, H. Yanai, T. Shimamura & *T. Osawa, “Acidic extracellular pH drives accumulation of N1-acetylspermidine and recruitment of protumor neutrophils”, PNAS Nexus, 2, pgad306 (2023). DOI: 10.1093/pnasnexus/pgad306 A01
  • Y. Muraoka, G. Yang, S. Munemasa, Y. Takeuchi, Y. Ishimaru, Y. Murata, N. Uozumi & *M. Ueda, “An outward-rectifying plant K+ channel SPORK2 exhibits temperature-sensitive ion transport activity”, Curr. Biol., 33, 5488-5494 (2023). DOI: 10.1016/j.cub.2023.10.057 A01
  • K. Noritsugu, T. Suzuki, K. Dodo, K. Ohgane, Y. Ichikawa, K. Koike, S. Morita, T. Umehara, K. Ogawa, M. Sodeoka, N. Dohmae, *M. Yoshida & *A. Ito, “Lysine long-chain fatty acylation regulates the TEAD transcription factor”, Cell Rep., 42, 112388 (2023). DOI: 10.1016/j.celrep.2023.112388 A01
  • K.R. Iyer, S.C. Li, N.M. Revie, J.W. Lou, D. Duncan, S. Fallah, H. Sanchez, I. Skulska, M.M. Ušaj, H. Safizadeh, B. Larsen, C. Wong, A. Aman, T. Kiyota, M. Yoshimura, H. Kimura, H. Hirano, M. Yoshida, H. Osada, A.C. Gingras, D. R Andes, R.S. Shapiro, N. Robbins, M.T. Mazhab-Jafari, L. Whitesell, *Y. Yashiroda, *C. Boone & *L.E. Cowen, “Identification of triazenyl indoles as inhibitors of fungal fatty acid biosynthesis with broad-spectrum activity”, Cell Chem. Biol., 30, 795-810.e8 (2023). DOI: 10.1016/j.chembiol.2023.06.005 A01B01
  • M. Nishiura, Y. Hori, M. Umeno & *K. Kikuchi, “Visualization of Multiple Localizations of GLUT4 by Fluorescent Probes of PYP-tag with Designed Unnatural Warhead”, Chem. Sci., 14, 5925-5935 (2023). DOI: 10.1039/D3SC00724c A01
  • *Y. Nishiga, S. Takase, T. Sumiya, K. Kikuzato, T. Sato, H. Niwa, S. Sato, A. Nakata, T. Sonoda, N. Hashimoto, R. Namie, T. Honma, T. Umehara, M. Shirouzu, H. Koyama, M. Yoshida, A. Ito & *F. Shirai, “Discovery of Novel Substrate-Competitive Lysine Methyltransferase G9a Inhibitors as Anticancer Agents”, J. Med. Chem., 66, 4059-4085(2023). DOI: 10.1021/acs.jmedchem.2c02059 A01
  • T. Matsuoka, A. Hattori, S. Oishi, M. Araki, T. Fujii, N. Arichi, Y. Okuno, H. Kakeya, S. Yamazaki, *H. Ohno & *S, Inuki, “Establishment of the MR1-presentation reporter screening system and identification of phenylpropanoid derivatives as MR1 ligands“, J. Med. Chem., 66, 12520-12535 (2023). DOI: 10.1021/acs.jmedchem.3c01122 A01
  • K. Torii, Y. Hori & *K. Kikuchi, “Persistent Fluorescence Switching of a Probe Using a Photochromic Quencher with High Photostability Assisted by Protein-Surface Modification”, Anal. Chem., 95, 8834-8841 (2023). DOI: 10.1021/acs.analchem.3c00163 A01
  • J. Wang, O.B. Fasina, M. Manzoor, Y. Wang, Q. Liu, J. Mo, H. Ohno, H. Osada, L. Xiang & *J. Qi, “A new gentiopicroside derivative improves cognitive deficits of AD mice via activation of Wnt signaling pathway and regulation of gut microbiota homeostasis“, Phytomedicine, 113, 154730 (2023). DOI: 10.1016/j.phymed.2023.154730 B01
  • T. Ochiai, T. Inukai, M. Akiyama, K. Furui, M. Ohue, N. Matsumori, S. Inuki, M. Uesugi, T. Sunazuka, K. Kikuchi, H. Kakeya & *Y. Sakakibara, “Variational autoencoder-based chemical latent space for large molecular structures with 3D complexity”, Commun. Chem., 6, 249 (2023). DOI: 10.1038/s42004-023-01054-6 A01B01
  • M. Dubol, J. Immenschuh, My Jonasson, K. Takahashi, T. Niwa, T. Hosoya, S. Roslin, J. Wikström, G. Antoni, Y. Watanabe, M. Lubberink, A. Biegon, I. Sundström-Promaa & *E. Comasco, “Acute nicotine exposure blocks aromatase in the limbic brain of healthy women: A [11C]cetrozole PET study”, Compr. Psychiatry, 123, 152381 (2023). DOI: 10.1016/j.comppsych.2023.152381 C01
  • *Y. Furutani, Y. Hirano, M. Toguchi, S. Higuchi, X-Y. Qin, K. Yanaka, Y. Sato-Shiozaki, N. Takahashi, M. Sakai, P. Kongpracha, T. Suzuki, N. Dohmae, M. Kukimoto-Niino, M. Shirouzu, S. Nagamori, H. Suzuki, K. Kobayashi, T. Masaki, H. Koyama, K. Sekiba, M. Otsuka, K. Koike, M. Kohara, S. Kojima, H. Kakeya & T. Matsuura, “A small chemical compound iCDM-34 identified by in silico screening suppresses HBV DNA through activation of arylhydrocarbon receptor”, Cell Death Discov., 9, 216 (2023). DOI: 10.1038/s41420-023-01755-w A01
  • *H. Kobayashi, S. Takase, H. Nishimura, K. Matsumoto, H. Harada & *M. Yoshida, “RNAi screening reveals a synthetic chemical-genetic interaction between ATP synthase and PFK1 in cancer cells”, Cancer Sci., 114, 1663-1671 (2023). DOI: 10.1111/cas.15713 A01
  • S. Shimizu, J. Kondo, K. Onuma, R. Coppo, K. Ota, M. Kamada, Y. Harada, Y. Tanaka, M. Adachi Nakazawa, Y. Tamada, Y. Okuno, K. Kawada, K. Obama, R. J Coffey, Y. Fujiwara & *M. Inoue, “Inhibition of the bone morphogenetic protein pathway suppresses tumor growth through downregulation of epidermal growth factor receptor in MEK/ERK-dependent colorectal cancer”, Cancer Sci., 114, 3636-3648 (2023). DOI: 10.1111/cas.15882 B01
  • *G. Yang, H. Xie, C. Wang, C. Zhang, L. Yu, L. Zhang, R. Xu, Z. Song, R. Liu & M. Ueda, “Design, synthesis, and discovery of Eudistomin Y derivatives as lysosome-targeted antiproliferation agents“, Eur. J. Med. Chem., 250, 115193 (2023). DOI: 10.1016/j.ejmech.2023.115193 A01
  • *F.H.P. Tan, A.C.J. Ting, N. Najimudin, N. Watanabe, S. Shamsuddin, A. Zainuddin, H. Osada & *G. Azzam, “3-[[(3s)-1,2,3,4-tetrahydroisoquinoline-3-carbonyl]amino]propanoic acid (thicapa) is protective against aβ42-induced toxicity in vitro and in an alzheimer's disease drosophila“, J. Gerontol. A Biol. Sci. Med. Sci., 78, 1944-1952 (2023). DOI: 10.1093/gerona/glad169 B01
  • K. Hayashi, N. Kato, K. Bashir, H. Nomoto, M. Nakayama, A. Chini, S. Takahashi, H. Saito, R. Watanabe, Y. Takaoka, M. Tanaka, A. Nagano, M. Seki, R. Solano & *M. Ueda, “Subtype-selective agonists of plant hormone co-receptor COI1-JAZs identified from the stereoisomers of coronatine“, Commun. Biol., 6, 320 (2023). DOI: 10.1038/s42003-023-04709-1 A01
  • T. Ito, T.D. Nguyen, Y. Saito, Y. Kurumida, H. Nakazawa, S. Kawada, H. Nishi, K. Tsuda, *T. Kameda & *M. Umetsu, “Selection of target-binding proteins from the information of weakly enriched phage display libraries by deep sequencing and machine learning“, mAbs., 15, 2168470 (2023). DOI: 10.1080/19420862.2023.2168470 B01
  • A. Kumar, M. Matsuoka, A. Matsuyama, *M. Yoshida & *K.Y.J. Zhang, “Identification of Fungal and Bacterial Denitrification Inhibitors Targeting Copper Nitrite Reductase”, J. Agric. Food Chem., 71, 5172-5184 (2023). DOI: 10.1021/acs.jafc.3c00896 A01
  • R. Saito, T. Muto, H. Urano, T. Kitajima, N. Kato, E. Kwon & *M. Ueda, “(3R, 7S)-12-Hydroxy- jasmonoyl-L-isoleucine is the genuine bioactive form of a jasmonate metabolite in Arabidopsis thaliana”, Plant J., 115, 709-723 (2023). DOI: 10.1111/tpj.16256　Selected as a Faculty Opinions article. A01
  • N. Saeki, C. Yamamoto, Y. Eguchi, T. Sekito, S. Shigenobu, M. Yoshimura, Y. Yashiroda, C. Boone & *H. Moriya, “Overexpression profiling reveals cellular requirements in the context of genetic backgrounds and environments”, PLoS Genet., 19, e1010732 (2023). DOI: 10.1371/journal.pgen.1010732 A01
  • S. Taniguchi, Y. Ono, Y. Doi, S. Taniguchi, Y. Matsuura, A. Iwasaki, N. Hirata, R. Fukuda, K. Inoue, M. Yamaguchi, A. Tashiro, D. Egami, S. Aoki, Y. Kondoh, K. Honda, H. Osada, H. Kumeta, T. Saio & *T. Okiyoneda, “Identification of α-Tocopherol succinate as an RFFL-substrate interaction inhibitor inducing peripheral CFTR stabilization and apoptosis“, Biochem. Pharmacol., 215, 115730 (2023). DOI: 10.1016/j.bcp.2023.115730 B01
  • R. Coppo, J. Kondo, K. Iida, M. Okada, K. Onuma, Y. Tanaka, M. Kamada, M. Ohue, K. Kawada, K. Obama & *M. Inoue, “Distinct but interchangeable subpopulations of colorectal cancer cells with different growth fates and drug sensitivity”, iScience, 26, 105962 (2023). DOI: 10.1016/j.isci.2023.105962 B01
  • M. Iwamoto, M. Morito, S. Oiki, Y. Nishitani, D. Yamamoto & *N. Matsumori, “Cardiolipin binding enhances KcsA channel gating via both its specific and dianion-monoanion interchangeable site”, iScience, 26, 108471 (2023). DOI: 10.1016/j.isci.2023.108471 A01
  • T. Kosugi & *M. Ohue, “Design of cyclic peptides targeting protein-protein interactions using AlphaFold”, Int. J. Mol. Sci., 24, 13257 (2023). DOI: 10.3390/ijms241713257 B01
  • Z. Liu, K. Ishikawa, E. Sanada, K. Semba, J. Li, X. Li, *H. Osada & *N. Watanabe, “Identification of antimycin A as a c-Myc degradation accelerator via high-throughput screening“, J. Biol. Chem., 299, 105083 (2023). DOI: 10.1016/j.jbc.2023.105083 B01
  • Z. Liu, Y. Yashiroda, P. Sun, H. Ma, Y. Wang, L. Li, F. Yan & *Y. Sun, “Argenteolides A and B, Glycosylated Polyketide-Peptide Hybrid Macrolides from an Actinomycete Streptomyces argenteolus”, Org. Lett., 25, 571-575 (2023). DOI: 10.1021/acs.orglett.2c03290 A01
  • S. Okuda, *C. Tsukano & K. Irie, “Synthesis of Stereoisomeric Simplified Analogs of Alotaketals toward the Elucidation of the Structural Requirements of Protein Kinase C Isozyme-Selective Binding”, Org. Lett., 25, 805-809 (2023). DOI: 10.1021/acs.orglett.2c04328 C01
  • J. Taguchi, T. Okuyama, S. Tomita, T. Niwa & *T. Hosoya, “Synthesis of Multisubstituted Aromatics via 3-Triazenylarynes”, Org. Lett., 25, 7030-7034 (2023). DOI: 10.1021/acs.orglett.3c02615 C01
  • *T. Niwa, T. Takimoto, Y. Sakata & *T. Hosoya, “Palladium-Catalyzed ipso-Borylation of Aryl Halides Promoted by Lewis Acid-Mediated Electrophilic Activation of Aryl(halo)palladium(II) Complex”, Org. Lett., 25, 8173-8177 (2023). DOI: 10.1021/acs.orglett.3c03531 C01
  • J. Zhang, K. Suzuki & *K. Ohmori, “Total Synthesis of Sparsomycin and Sparoxomysins A1 and A2 via Sulfenate-Anion-Mediated Iterative C-S Bond Formation”, Org. Lett., 25, 9036-9040 (2023). DOI: 10.1021/acs.orglett.3c03791 C01
  • Y. Ogawa, Y. Saito, H. Yamaguchi, *Y. Katsuyama & Y. Ohnishi, ” Engineering the substrate specificity of toluene degrading enzyme XylM using biosensor XylS and machine learning”, ACS Synthetic Biology, 12, 572-582 (2023). DOI: 10.1021/acssynbio.2c00577 B01
  • M. Ozaki, M. Shimotsuma, T. Kuranaga, *H. Kakeya & *T. Hirose,” Separation of amyloid β fragment peptides with racemised and isomerised aspartic acid residues using an original chiral resolution labeling reagent”, Analyst, 148, 1209-1213 (2023). DOI: 10.1039/d2an01885c A01
  • Y. Pan, T. Suzuki, K. Sakai, Y. Hirano, H. Ikeda, A. Hattori, N. Dohmae, K. Nishio, *H. Kakeya & A. Bisabosqual, “A novel asparagine synthetase inhibitor suppressing the proliferation and migration of human non-small cell lung cancer A549 cells” Eur. J. Pharmacol., 960, 176156 (2023). DOI: 10.1016/j.ejphar.2023.17615 A01
  • T. Niwa, T. Tahara, C.E. Chase, F.G. Fang, T. Nakaoka, S. Irie, E. Hayashinaka, Y. Wada, H. Mukai, K. Masutomi, Y. Watanabe, Y. Cui & *T. Hosoya, “Synthesis of 11C-Radiolabeled Eribulin as a Companion Diagnostics PET Tracer for Brain Glioblastoma”, Bull. Chem. Soc. Jpn., 96, 283-290 (2023). DOI: 10.1246/bcsj.20220335 C01
  • Y. Kumagai, Y. Saito & *Y.S. Kida, ”A multiomics atlas of brown adipose tissue development over time,” Endocrinology, 164, bqad064 (2023). DOI: 10.1210/endocr/bqad064 B01
  • J. Fu, Y. Nakata, H. Itoh, S. Panthee, H. Hamamoto, K. Sekimizu & *M. Inoue, “Molecular Editing Enhances Oxidation Resistance of Menaquinone-Targeting Antibiotics Lysocin E and WAP-8294A2“, Chem. Eur. J., 29, e202301224 (2023). DOI: 10.1002/chem.202301224 C01
  • Y. Nakata, J. Fu, H. Itoh, S. Panthee, H. Hamamoto, K. Sekimizu & *M. Inoue, “Construction of Five Tryptophan Isomers and Application of the Isomers to Solid-Phase Total Syntheses of Lysocin E Derivatives“, Chem. Eur. J., 29, e202301225 (2023). DOI: 10.1002/chem.202301225 C01
  • H. Inagaki, K. Hayashi, Y. Takaoka, H. Ito, Y. Fukumoto, A. Yajima, X. Chen, M. Shimosato, E. Hasett, K. Hatakeyama, Y. Hirakuri, M. Ishitsuka, E. Yumoto, T. Sakazawa, M. Asahina, K. Uchida, K. Okada, H. Yamane, M. Ueda & *K. Miyamoto,” Genome Editing Approach Revealed a Crucial Role of OsCOI2 in Jasmonate Signaling and Functional1 Diversity of COI1 Homologs in Rice”, Plant Cell Physiol., 64, 405-421 (2023). DOI: 10.1093/pcp/pcac166 A01
  • *M. Ohue, Y. Kojima & T. Kosugi, “Generating potential protein-protein interaction inhibitor molecules based on physicochemical properties”, Molecules, 28, 5652 (2023). DOI: 10.3390/molecules28155652 B01
  • Y. Xue, K. Miura, H. Itoh & *M. Inoue, “C-Terminal Modification of Polytheonamide B Uncouples Its Dual Functions in MCF-7 Cancer Cells“, Chem. Commun., 59, 3914-3917 (2023). DOI: 10.1039/D2CC05915K C01
  • Y. Matsui, T. Kowada, Y. Ding, P.R. Sahoo, K. Kikuchi & *S. Mizukami, “Long-term Imaging of Intranuclear Mg2+ Dynamics during Mitosis using a Localized Fluorescent Probe”, Chem. Commun., 59, 7048-7051 (2023). DOI: 10.1039/d2cc05930d A01
  • B. Chen, Md. M. Hasan, H. Zhang, Q. Zhai, A. S. M. Waliullah, Y. Ping, C. Zhang, S. Oyama, Mst. A. Mimi, Y. Tomochika, Y. Nagashima, T. Nakamura, T. Kahyo, K. Ogawa, D. Kaneda, M. Yoshida & *M. Setou, “UBL3 Interacts with Alpha-Synuclein in Cells and the Interaction Is Downregulated by the EGFR Pathway Inhibitor Osimertinib”, Biomedicines., 11, 1685 (2023). DOI: 10.3390/biomedicines11061685 A01
  • J. Yan, H. Zhang, Y. Tomochika, B. Chen, Y. Ping, S. Islam, S. Aramaki, T. Sato, Y. Nagashima, T. Nakamura, T. Kahyo, D. Kaneda, K. Ogawa, M. Yoshida & *M. Setou, “UBL3 Interaction with α-Synuclein Is Downregulated by Silencing MGST3”, Biomedicines., 11, 2491 (2023). DOI: 10.3390/biomedicines11092491 A01
  • *M. Ueda, N. Kato, Y. Kurata, M. Imai, G. Yang & K. Taniguchi, “Host-selective phytotoxins incorporating the epoxy-triene-decacarboxylate moiety function through the hijacking of the plant-microbe interaction system”, ACS Chem. Biol., 18, 12-17 (2023). DOI: 10.1021/acschembio.2c00777 A01
  • T. Motoyama, T. Nogawa, T. Shimizu, M. Kawatani, T. Kashiwa, C.S. Yun, D. Hashizume & *H. Osada “Fungal NRPS-PKS Hybrid Enzymes Biosynthesize New γ-Lactam Compounds, Taslactams A-D, Analogous to Actinomycete Proteasome Inhibitors“, ACS Chem. Biol., 18, 396-403 (2023). DOI: 10.1021/acschembio.2c00830 B01
  • *K. Miyamoto, N. Yamamoto & Y. Sakakibara, “Quantum algorithm for position weight matrix matching”, IEEE Trans. Quantum Eng., 4, 1-14 (2023). DOI: 10.1109/TQE.2023.3293562 B01
  • Y. Akutsu, T. Fujiwara, R. Suzuki, Y. Nishigaya & *T. Yamazaki, “Juglone, a Plant-Derived 1,4-Naphthoquinone, Binds to Hydroxylamine Oxidoreductase and Inhibits the Electron Transfer to Cytochrome c554” App. Environ. Microbiol., 89, e0129123, (2023). DOI: 10.1128/aem.01291-23 A01
  • *N. Kato, K. Ebihara, T. Nogawa, Y. Futamura, K. Inaba, A. Okano, H. Aono, Y. Fujikawa, H. Inoue, K. Matsuda, H. Osada, R. Niwa & S. Takahashi, “Cis-decalin-containing tetramic acids as inhibitors of insect steroidogenic glutathione s-transferase noppera-bo“, PLoS ONE,18, e0290851 (2023). DOI: 10.1371/journal.pone.0290851 B01
  • M. Ozaki, M. Shimotsuma, T. Kuranaga, *H. Kakeya & *T. Hirose, “Simultaneous separation and identification of all structural isomers and enantiomers of aminobutyric acid using a highly sensitive chiral resolution labeling reagent” Anal. Methods, 15, 6648-6655 (2023). DOI: 10.1039/D3AY01665J A01
  • C. Okuda, Y. Ueda, M. Muroi, E. Sanada, H. Osada, Y. Shiono, K.I. Kimura, K. Takeda, K. Kawaguchi & *T. Kataoka “Allantopyrone A interferes with the degradation of hypoxia-inducible factor 1α protein by reducing proteasome activity in human fibrosarcoma HT-1080 cells“, J. Antibiot., 76, 324-334 (2023). DOI: 10.1038/s41429-023-00610-5 B01
  • T. Nogawa, N. Kato, T. Shimizu, A. Okano, Y. Futamura, S. Takahashi, H. Koshino & *H. Osada, “Wakodecaline C, new tetrahydrofuran-fused decalin metabolite isolated from fungus Pyrenochaetopsis sp. RK10-F058“, J. Antibiot., 76, 346-350 (2023). DOI: 10.1038/s41429-023-00613-2 B01
  • Y. Awano, H. Tsutsumi, Y. Kikuchi, A. Kimishima, M. Iwatsuki, Y. Asami & *Y. Inahashi “Emblestatin: a new peptide antibiotic from Embleya scabrispora K20-0267”, J. Antibiot., 76, 592-592 (2023). DOI: 10.1038/s41429-023-00645-8 A01
  • N. Hatano, *M. Kamada, R. Kojima, *Y. Okuno, “Network-based prediction approach for cancer-specific driver missense mutations using a graph neural network”, BMC bioinformatics, 24, 383 (2023). DOI: 10.1186/s12859-023-05507-6 B01
  • N. Usukhbayar, Y. Takano, S. Uesugi, M. Muroi, H. Osada & *K.I. Kimura, “3,6-Epidioxy-1,10-bisaboladiene induces ferroptosis-like cell death through lipid peroxidation“, Free Radic. Res., 57, 208-222 (2023). DOI:10.1080/10715762.2023.2229005 B01
  • S. Sekine, S. Takase, R. Hayase, K. Noritsugu, Y. Maemoto, Y. Ichikawa, K. Ogawa, Y. Kondoh, H. Osada, M. Yoshida & *A. Ito, “Identification of a derivative of the alkaloid emetine as an inhibitor of the YAP-TEAD interaction and its potential as an anticancer agent”, Biosci. Biotechnol. Biochem., 98, 501-510 (2023). DOI:  10.1093/bbb/zbad022 A01
  • S. Sekine, S. Takase, R. Hayase, K. Noritsugu, Y. Maemoto, Y. Ichikawa, K. Ogawa, Y. Kondoh, H. Osada, M. Yoshida & *A. Ito, “Identification of a derivative of the alkaloid emetine as an inhibitor of the YAP-TEAD interaction and its potential as an anticancer agent“, Biosci. Biotechnol. Biochem., 87, 501-510 (2023). DOI: 10.1093/bbb/zbad022 B01
  • T. Okumura, T. Kitajima, T. Kaji, H. Urano, K. Matsumoto, H. Inagaki, K. Miyamoto, K. Okada & *M. Ueda, “Difference in the ligand affinity among redundant plant hormone receptors of rice OsCOI1a/1b/2-OsJAZs”, Biosci. Biotechnol. Biochem., 87,1122-1128 (2023). DOI: 10.1093/bbb/zbad092 A01
  • S. Yamamoto, I. Sato, M. Fujii, M. Kakimoto, K. Honma, S. Kirihara, H. Nakayama, T. Fukuoka, S. Tamura, M. Ueda, S. Hirohata & *S. Watanabe, “Therapeutic effect of ouabagenin, a novel liver X receptor agonist, on atherosclerosis in nonalcoholic steatohepatitis in SHRSP5/Dmcr rat model”, Can. J. Physiol. Pharmacol.,101, 455-465 (2023). DOI: 10.1139/cjpp-2022-0532 A01
  • J. Zhang, V.V. Betkekar, K, Suzuki & *K. Ohmori, “Diastereoselective Access to anti-b-Hydroxy Sulfoxides from Chiral Epoxides and Prochiral Sulfenate Anions: Mechanistic Insights, Scope and Limitation”, Synlett, 34, A-G (2023). DOI: 10.1055/a-2196-5592 C01
  • R. Yagita, K. Irie & *C. Tsukano, “Toward the Total Synthesis of Schinortriterpenoids: Construction of the all-cis-substituted cyclopropane unit”, Synlett, 34, eFirst (2023). DOI: 10.1055/a-2102-8014 C01
  • M. Ozaki, M. Shimotsuma, T. Kuranaga, *H. Kakeya & *T. Hirose, ”Separation and identification of isoleucine enantiomers and diastereomers using an original chiral resolution labeling reagent”, Chem. Pharm. Bull., 11, 824-831 (2023). DOI: 10.1248/cpb.c23-00439 A01
  • *M. Ohue, “MEGADOCK-on-Colab: an easy-to-use protein-protein docking tool on Google Colaboratory”, BMC Res. Notes, 16, 229 (2023). DOI: 10.1186/s13104-023-06505-w B01
  • X. Liu, E. Sanada, J. Li, X. Li, *H. Osada & *N. Watanabe, “Isolation and characterization of β-transducin repeat-containing protein ligands screened using a high-throughput screening system“, Oncol. Res., 31, 645-654 (2023). DOI:10.32604%2For.2023.030240 B01
  • Z. Liu, A. Okano, E. Sanada, Y. Futamura, T. Nogawa, K. Ishikawa, K. Semba, J. Li, X. Li, *H. Osada & *N. Watanabe, “Identification of microbial metabolites that accelerate the ubiquitin-dependent degradation of c-Myc“, Oncol. Res., 31, 655-666 (2023). DOI: 10.32604%2For.2023.030248 B01
  • *M. Kawatani, H. Aono, S. Hiranuma, T. Shimizu, M. Muroi, T. Nogawa, T. Ohishi, S.I. Ohba, M. Kawada, K. Yamazaki, S. Dan, N. Dohmae & *H. Osada, “Identification of a dihydroorotate dehydrogenase inhibitor that inhibits cancer cell growth by proteomic profiling“, Oncol. Res.,31, 833-844 (2023). DOI: 10.32604/or.2023.030241 B01
  • M. Sasaki, *S. Nishimura, A. Matsuyama & *M. Yoshida, ”Protocol for detecting threonine deaminase activity in fission yeast cell lysates”, STAR Protoc., 4, 102675 (2023). DOI: 10.1016/j.xpro.2023.102675 A01
  • K. Inoue, *R. Kojima, M. Kamada & *Y. Okuno, “An end-to-end framework for gene expression classification by integrating a background knowledge graph: application to cancer prognosis prediction”, arXiv., (2023). DOI:10.48550/arXiv.2306.17202 B01
  • K. Furui & M. Ohue, “Faster Lead Optimization Mapper Algorithm for Large-Scale Relative Free Energy Perturbation”, Proceedings of The 29th International Conference on Parallel & Distributed Processing Techniques and Applications (PDPTA’23), in press (2023). https://arxiv.org/pdf/2304.04713.pdf B01
  • T. Ueki & M. Ohue, “Antibody Complementarity-Determining Region Sequence Design using AlphaFold2 and Binding Affinity Prediction Model”, Proceedings of The 29th International Conference on Parallel & Distributed Processing Techniques and Applications (PDPTA’23), in press (2023). Antibody Complementarity-Determining Region Sequence Design using AlphaFold2 and Binding Affinity Prediction Model - Abstract - Europe PMC B01
  • A. Kengkanna & M. Ohue, “Enhancing Model Learning and Interpretation Using Multiple Molecular Graph Representations for Compound Property and Activity Prediction”, Proceedings of The 20th IEEE International Conference on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB 2023), 8 pages (2023). DOI: 10.1109/CIBCB56990.2023.10264879 B01
  • K. Murakumo, N. Yoshikawa, K. Rikimaru, S. Nakamura, K. Furui, T. Suzuki, H. Yamasaki, Y. Nishigaya, Y. Takagi & M. Ohue, “LLM Drug Discovery Challenge: A Contest as a Feasibility Study on the Utilization of Large Language Models in Medicinal Chemistry”, Proceedings of AI for Accelerated Materials Design (AI4Mat) NeurIPS 2023 Workshop (2023). B01
  • B. Bian, T. Kumagai & *Y. Saito, “VeloPro: A pipeline integrating Ribo-seq and AlphaFold deciphers association patterns between translation velocity and protein structure features among prokaryotic and eukaryotic organisms” iMeta, 2, 4, e148 (2023). DOI: 10.1002/imt2.148 B01

特許

2024年

  • 「アミロイド協働型酵素反応の開発」、出願人：和歌山県立医科大学、発明者：相馬洋平、澤崎鷹、特願2024-85621：2024年5月27日 A01
  • 「タンパク質相互作用を検出する方法」、出願人：大阪大学、発明者：蓑島維文、Jiatong Li、菊地和也、特願2024-31686：2024年3月1日 A01
  • 「抗がん剤」、出願人：京都大学、発明者：掛谷秀昭、池田拓慧、柴崎守弘、特願2024-017369：2024年2月7日 A01
  • 「ホウ素中性子捕獲治療用アルブミンナノプラットフォーム及びそれを含むホウ素中性子捕獲治療用組成物（붕소중성자포획치료용 알부민 나노플랫폼 및 이를 포함하는 붕소중성자포획치료용 조성물）」、出願人：Seoul National University、発明者：Yun-Sang Lee、Ji Yong Park、Takamitsu Hosoya、Takashi Niwa、1020240014785（大韓民国）：2024年1月31日出願 C01

2023年

  • 「ペプチド系抗がん活性化合物」、出願人：東京大学、発明者：井上将行、伊藤寛晃、PCT/JP2023/42956：2023年11月30日 C01
  • 「イソインドリン誘導体」、出願人：理化学研究所、京都大学、発明者：古谷裕、須藤正幸、松浦知和、掛谷秀昭、ルトガー・フォルマー、マルティン・エールランド、特願2023-184174：2023年10月26日 A01
  • 「コロナウイルス感染症を処置することに用いられる抗体」、出願人：理化学研究所、東京大学、滋賀医科大学、発明者：齊藤隆、原田通成、白水美香子、松本武久、出井晶子、井上純一郎、山本瑞生、合田仁、川口寧、伊藤靖、石垣宏仁、仲山美沙子、北川善紀、出願番号：PCT/JP2023/014855、出願日：2023年4月12日、公開番号：WO/2023/199943、公開日：2023年10月19日 A01
  • 「新規アミド化反応」、出願人：京都大学、発明者：掛谷秀昭、倉永健史、小山愛、特願2023-147238：2023年9月11日 A01
  • 「Compounds as antifungal agents, derivatives thereof and novel compounds」、出願人：The University of Tokyo、発明者：Y. Ohya K. Nakama, W. Liu, H. Sekiguchi, Y. Yashiroda, C. Boone, D. Yamanaka、63/578668：2023年8月25日 A01
  • 「新規ピラゾール誘導体及びその用途」、出願人：国立研究開発法人理化学研究所、公益財団法人がん研究会、発明者：風見純一、清宮啓之、吉田稔、八代田陽子、特願2022-125550：2022年8月5日、PCT/JP2023/28365：2023年8月3日 A01
  • 「光反応性金ナノクラスター及び中間体」、出願人：理化学研究所、発明者：渡邊賢司、丹羽 節、細谷孝充、特願2023-109316：2023年7月3日 C01
  • 「フラノクマリン誘導体およびその用途」、出願人：静岡県公立大学法人、国立研究開発法人理化学研究所、国立感染症研究所、発明者： 渡辺賢二、長田裕之、渡邊正悟、川谷誠、中嶋章悟、日紫喜隆行、渡士幸一、特願2023-013326：2023年1月31日 B01

書籍、解説記事等

2024年

  • 松森信明、「脂質は膜タンパク質の影の立役者　両者の分子間相互作用を明らかにするための解析手法」、月刊「化学」（化学同人）、79、 72-73 (2024) A01
  • 掛谷秀昭、「医薬品モダリティの開発を指向した天然物創薬ケミカルバイオロジー」、医薬品モダリティにおける創薬技術開発と展望、情報機構、193-204(2024) A01
  • K. Ohmori, K. Suzuki, "Fluoroarene Strategy in Total Synthesis of Natural Flavonoids (Chapter 8)", Modern Natural Product Synthesis Overcoming Difficulties, M. Nakada, K. Tanino, K. Nagasawa, S. Yokoshima, Springer, 163–179 (2024) C01
  • 村岡勇樹、上田 実、化学掲示板「長年の謎・植物の温度センサー分子を発見！」、月刊化学（化学同人）(2024) A01
  • 丹羽 節、細谷孝充、「複雑な構造を有するPETプローブの開発」、アイソトープニュース, 792, 2-6 (2024) C01
  • 丹羽 節、喜井 勲、細谷孝充、「clickable光親和性標識プローブを用いた標的分子同定」実験医学増刊：あなたのラボから薬を生み出す アカデミア創薬の実践 All JAPAN体制の先端技術支援を利用した創薬の最前線化学、善光龍哉、辻川和丈（編）、羊土社、205-211 (2024) 、 2024年2月1日発行 C01
  • 丹羽 節、田原 強、Charles E. Chase、Francis G. Fang、中岡貴義、入江さつき、林中恵美、和田康弘、向井英史、増富健吉、渡辺恭良、崔翼龍、細谷孝充、「脳膠芽腫のコンパニオン診断用PETトレーサーとしての[11C]エリブリンの合成」、JSMI Report、17、30-33 (2024) C01
  • J. Sakamoto & *H. Ishikawa, “Collective Total Synthesis of Secologanin-Related Natural Products”, Modern Natural Product Synthesis, Springer, Singapore, M. Nakada, K. Tanino, K. Nagasawa, S. Yokoshima, 181–204, 2024 C01
  • 石川勇人、「天然物全合成のためのテーラーメード有機触媒反応の開発」、有機合成化学協会誌、82, 473－482、2024 C01

2023年

  • 小西祐輝、蓑島維文、菊地和也、「MRIの現在と未来-マルチカラー19F MRIがもたらすもの」、化学12月号、12、 62-63 (2023) A01
  • 蓑島維文、菊地和也、「生命機能を可視化するさまざまな化学蛍光プローブ」、医学のあゆみ7月生体イメージングの最前線、白石泰夫（編）、医歯薬出版株式会社、337-342 (2023) A01
  • 掛谷秀昭、「創薬リード探索へのケモインフォマティクスの応用　ケモインフォマティクスにおけるデータ収集の最適化と解析方法～組成予測や化学構造の生成・合成経路探索や反応条件最適化・毒性評価～」、技術情報協会、519-526 (2023) A01
  • 掛谷秀昭、新講座・天然物化学① 「天然有機化合物と”くすり”」、日本化学会「化学と教育」、71、 492-495 (2023) A01
  • 奥村太知、上田 実、香りの化学「ジャスモン酸と植物の香りのケミカルバイオロジー」、化学と教育、73、98-101 (2023) A01
  • 長田裕之、「新薬創製談話会とブロススクリーニングネットワーク備忘録」、Actinomycetologica、 37、 94-101 (2023) B01
  • 長田裕之、「天は自ら助くる者を助く」、有機合成化学協会誌、81、 1194-1197 (2023) B01
  • 野川俊彦、植木雅志、長田裕之、「微生物に新規物質を求めて」、未培養微生物研究の最新動向、青柳秀紀監修、シーエムシー出版、157-165 (2023) B01
  • 山口 秀輝、齋藤 裕、「タンパク質の言語モデル」 JSBi Bioinformatics Review、 4、 52-67 (2023) DOI: 10.11234/jsbibr.2023.1. B01
  • 大上雅史、「AlphaFoldによる高精度なタンパク質立体構造予測と創薬への応用」、PHARM STAGE、 23、 24-28 (2023) B01
  • 大上雅史、「AlphaFoldによるタンパク質立体構造予測（実践編）」、生物工学会誌 2023年8月号、 101、 443-446 (2023). DOI: 10.34565/seibutsukogaku.101.8_443 B01
  • 大上雅史、「PPI（タンパク質間相互作用）を標的とするドラッグデザイン」、タンパク質の構造解析手法とIn silicoスクリーニングへの応用事例、技術情報協会、402-410 (2023) B01
  • 大上雅史、「AIによって変わる生命科学」、現代化学 2023年8月号、東京化学同人、28-30 (2023) B01
  • 大森　建、「未踏の化合物空間：高次構造フラボノイドの合成研究」現代化学増刊47：有機化学イノベーション、山本尚（監修）、東京化学同人、155-169 (2023) C01
  • 大森 建、「カルタミン合成における試行錯誤」ドラマティック有機合成化学：感動の瞬間100、有機合成化学協会（編）、化学同人、69-69 (2023) C01
  • 大森 建、「最新のトピックス　キラリティーをリサイクルする−逆転の発想：キラルスルホキシドの光ラセミ化」、月刊化学、vol.78（11月号）、66-67 (2023) C01
  • 塚野千尋、「歪んだ3員環を含む生物活性天然物の全合成」、化学と生物、 61、 288–295 (2023) C01
  • H. Itoh, “Discovery of Natural Product Analogues with Altered Activities by a High-Throughput Strategy,” New Tide of Natural Product Chemistry, H. Ishikawa and H. Takayama, eds., Springer, Singapore, 333-354 (2023)
    DOI: 10.1007/978-981-99-1714-3_16 C01